A growing body of literature suggests that cannabis intake can induce memory loss in humans and animals. Besides the recreational use, daily cannabis users may also belong to the ever-increasing population of patients who are administered cannabis as a medicine. As such, they also can experience impairments in memory as a negative side effect of their therapy. Comprehension of the neurobiological mechanisms responsible for such detrimental effects would be therefore of paramount relevance to public health. The investigation of neurobiological mechanisms in humans, despite the progress in the development of imaging technologies that allow the study of brain structure and function, still suffers substantial limitations. Animal models, instead, enable us to establish a causal relationship and thus to better elucidate the neurobiological mechanisms underlying the process under study. In this review, we will attempt to collect the insight coming from animal models about cannabis effects on memory, trying to depict a picture of the neurobiological mechanisms contributing to the development of cognitive deficits following cannabis use.

中文翻译：

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大麻引起的记忆障碍的神经生物学机制

越来越多的文献表明，摄入大麻会导致人类和动物的记忆力丧失。除了娱乐用途外，每天吸食大麻的人也可能属于不断增加的大麻作为药物的患者群体。因此，他们也可能会经历记忆障碍，这是他们治疗的负面副作用。因此，了解造成这种有害影响的神经生物学机制对公共卫生至关重要。尽管允许研究大脑结构和功能的成像技术的发展取得了进展，但对人类神经生物学机制的研究仍然受到很大的限制。动物模型，相反，使我们能够建立因果关系，从而更好地阐明所研究过程的神经生物学机制。在这篇综述中，我们将尝试收集来自动物模型的关于大麻对记忆影响的见解，试图描绘导致大麻使用后认知缺陷发展的神经生物学机制的图景。