As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complicated and result from multiple factors. Among them, non-coding RNAs (ncRNAs), along with their modifiers, have been investigated to play key roles in regulating tumor development and mediating therapy resistance within various cancers, such as hepatocellular carcinoma, breast cancer, lung cancer, gastric cancer, etc. In this review, we attempt to elucidate the mechanisms underlying ncRNA/modifier-modulated resistance to chemotherapy and radiotherapy, providing some therapeutic potential points for future cancer treatment.

中文翻译：

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非编码 RNA 和 RNA 修饰物在癌症治疗耐药中的作用。


作为癌症的标准治疗方法，化疗和放疗已广泛应用于全球临床实践。然而，癌症治疗的耐药性是临床和科学研究的重大挑战，导致肿瘤复发和转移。治疗抵抗的机制很复杂，是多种因素共同作用的结果。其中，非编码RNA（ncRNA）及其修饰物已被研究在调节肿瘤发展和介导各种癌症（如肝细胞癌、乳腺癌、肺癌、胃癌等）的耐药性中发挥关键作用在这篇综述中，我们试图阐明 ncRNA/修饰剂调节对化疗和放疗耐药的机制，为未来的癌症治疗提供一些潜在的治疗点。