Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer.

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胰腺癌的代谢：为更好的抗癌策略铺平道路。

胰腺癌目前是最致命的疾病之一。近年来，越来越多的证据表明，重新编程的代谢可能在胰腺癌的致癌，进展，治疗和预后中起关键作用。受内在或外在因素的影响，胰腺癌细胞采用广泛不同的代谢过程来满足其生长需求。肿瘤微环境中重新连接的葡萄糖，氨基酸和脂质代谢以及代谢串扰有助于胰腺肿瘤的无限发展。另外，与胰腺癌抗性有关的代谢重编程也与化学疗法，放射疗法和免疫疗法密切相关，并且导致不良的预后。反映新陈代谢的关键作用，有关针对胰腺癌的代谢靶向疗法的临床前和临床试验的数量正在增加。使用调节新陈代谢的疗法后，胰腺癌患者的不良预后可能会大大改善。因此，对代谢的研究不仅有益于癌变和癌症进展的理解，而且还为胰腺癌的治疗提供了新的见识。