Brucellosis is a worldwide zoonotic disease of socio‐economic importance. Understanding the association of this disease with pregnancy outcome has the potential of contributing to the reduction of its reproductive burden in humans and animals among pastoral communities in Tanzania. A prospective cohort study was conducted in Kagera Region on pregnant women (n = 76) and gravid ruminants (121 cattle, 125 goats and 111 sheep). Exposed and non‐exposed groups to brucellosis were followed for 6 months (from 15 November 2017 to 15 April 2018). Sera were collected and analysed using Rose Bengal Test (RBT) and Fluorescence polarization assay (FPA) test. Measures of effect, univariable and multivariable logistic regression analyses were computed. Positivity to both RBT and FPA tests was 21% (95% CI: 12.5–32) in pregnant women and 5% (95% CI: 3.1–8) in gravid ruminants. Among aborted cases, four women (out of nine), two cows (out of seven), two goats (out of 26) and zero sheep (out of 11) were positive to brucellosis. The abortion rate in humans and ruminants was 11.8% and 12.3%, respectively. Seropositivity to brucellosis was similar in aborted and non‐aborted cases in humans (p = .08) and in ruminants (p = .2). At the population level, brucellosis was associated with abortions (population attributable risk: PAR) at 3.5% in pregnant women and at 0.5% in gravid ruminants in the study area. Infections to brucellosis were increased in exposed pregnant women (OR = 19; 95% CI: 1.8–203, p = .01) and in cattle (OR = 11; 95% CI: 1.3–88, p = .02). There is an indication that brucellosis could be contributing to abortions in pregnant women and domestic ruminants Kagera Region. Molecular tools could support more the results from serological tests to avoid cross‐reaction with other pathogen agents. Control of brucellosis in animals is likely to reduce the threat of abortions in humans.

中文翻译：

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坦桑尼亚卡盖拉生态系统中布鲁氏菌病与人类和家养反刍动物流产的关联。

布鲁氏菌病是一种具有社会经济重要性的世界性人畜共患疾病。了解这种疾病与妊娠结局的关系有可能有助于减轻坦桑尼亚牧区人类和动物的生殖负担。在卡盖拉地区对孕妇（n  = 76）和妊娠反刍动物（121 头牛、125 头山羊和 111 头绵羊）进行了前瞻性队列研究。对暴露和未暴露于布鲁氏菌病的组进行了为期 6 个月的随访（从 2017 年 11 月 15 日至 2018 年 4 月 15 日）。使用孟加拉红测试（RBT）和荧光偏振测定（FPA）测试收集并分析血清。计算了效果测量、单变量和多变量逻辑回归分析。孕妇 RBT 和 FPA 检测的阳性率为 21% (95% CI: 12.5–32)，妊娠反刍动物的阳性率为 5% (95% CI: 3.1–8)。在流产病例中，四名妇女（共九名）、两头牛（共七名）、两只山羊（共 26 名）和零只绵羊（共 11 名）布鲁氏菌病呈阳性。人类和反刍动物的流产率分别为11.8%和12.3%。在人类 ( p  = .08) 和反刍动物 ( p = .2)的流产和非流产病例中，布鲁氏菌病血清阳性率相似 。在人群水平上，布鲁氏菌病与流产（人群归因风险：PAR）相关，在研究区域孕妇中为 3.5%，妊娠反刍动物中为 0.5%。接触过该病毒的孕妇（OR = 19；95% CI：1.8-203， p  = .01）和牛（OR = 11；95% CI：1.3-88，p  = .02）的布鲁氏菌病感染率增加。有迹象表明，布鲁氏菌病可能导致卡盖拉地区孕妇和家养反刍动物流产。分子工具可以更多地支持血清学测试的结果，以避免与其他病原体发生交叉反应。控制动物布鲁氏菌病可能会减少人类堕胎的威胁。