Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling,Allergy

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Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling
Allergy ( IF 12.6 ) Pub Date : 2020-04-24 , DOI: 10.1111/all.14254
Jelle Folkerts _{1,

2,

3,

4} , Frank Redegeld ₁ , Gert Folkerts ₁ , Bart Blokhuis ₁ , Mariska P M van den Berg ₅ , Marjolein J W de Bruijn ₂ , Wilfred F J van IJcken ₆ , Tobias Junt ₇ , See-Ying Tam ₃ , Stephen J Galli _{3,

8} , Rudi W Hendriks ₂ , Ralph Stadhouders _{2,

9} , Marcus Maurer ₄

Affiliation

Short‐chain fatty acids (SCFAs) are fermented dietary components that regulate immune responses, promote colonic health, and suppress mast cell–mediated diseases. However, the effects of SCFAs on human mast cell function, including the underlying mechanisms, remain unclear. Here, we investigated the effects of the SCFAs (acetate, propionate, and butyrate) on mast cell–mediated pathology and human mast cell activation, including the molecular mechanisms involved.

中文翻译：

丁酸盐通过 FcεRI 介导的信号传导的表观遗传调控抑制人肥大细胞活化

短链脂肪酸 (SCFA) 是发酵的膳食成分，可调节免疫反应、促进结肠健康并抑制肥大细胞介导的疾病。然而，SCFAs 对人类肥大细胞功能的影响，包括潜在的机制，仍不清楚。在这里，我们研究了 SCFA（乙酸盐、丙酸盐和丁酸盐）对肥大细胞介导的病理学和人类肥大细胞活化的影响，包括所涉及的分子机制。

更新日期：2020-04-24

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