Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring.,Molecular Nutrition & Food Research

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Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-03-17 , DOI: 10.1002/mnfr.201901178
Rola Hammoud ₁ , Emanuela Pannia ₁ , Ruslan Kubant ₁ , Chih-Sheng Liao ₁ , Mandy Ho ₁ , Neil V Yang ₁ , Diptendu Chatterjee ₁ , Marie A Caudill ₂ , Olga V Malysheva ₂ , Zdenka Pausova _{1,

3,

4} , G Harvey Anderson _{1,

3}

Affiliation

Scope: High‐folic‐acid diets during pregnancy result in obesity in the offspring, associated with altered DNA‐methylation of hypothalamic food intake neurons. Like folic acid, the methyl‐donor choline modulates foetal brain development, but its long‐term programing effects on energy regulation remain undefined. This study aims to describe the effect of choline intake during pregnancy on offspring phenotype and hypothalamic energy‐regulatory mechanisms.

中文翻译：

母体胆碱摄入计划下丘脑能量调节和雄性Wistar大鼠后代的晚年表型。

范围：怀孕期间的高叶酸饮食会导致后代肥胖，并与下丘脑食物摄取神经元的DNA甲基化改变有关。像叶酸一样，甲基供体胆碱可调节胎儿的大脑发育，但其对能量调节的长期编程作用仍然不确定。这项研究旨在描述怀孕期间摄入胆碱对后代表型和下丘脑能量调节机制的影响。

更新日期：2020-03-17

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