The widespread application of nanoparticles (NPs) in recent times has caused concern because of their effects in biological systems. Although NPs can be produced naturally, industrially synthesized NPs affect the metabolism of a given organism because of their high reactivity. The biotransformation of NPs involves different processes, including aggregation/agglomeration, and reactions with biomolecules that will be reflected in their toxicity. Several analytical techniques, including inductively coupled plasma mass spectrometry (ICP-MS), have been used for characterizing and quantifying NPs in biological samples. In fact, in addition to providing information regarding the morphology and concentration of NPs, ICP-MS-based platforms, such as liquid chromatography/ICP-MS, single-particle ICP-MS, field-flow fractionation (asymmetrical flow field-flow fractionation)-ICP-MS, and laser ablation-ICP-MS, yield elemental information about molecules. Furthermore, such information together with speciation analysis enlarges our understanding of the interaction between NPs and biological organisms. This study reports the contribution of ICP-MS-based platforms as a tool for evaluating NPs in distinct biological samples by providing an additional understanding of the behavior of NPs and their toxicity in these organisms.

中文翻译：

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基于感应耦合等离子体质谱的平台，用于研究生物样品中的纳米粒子效应。

由于纳米粒子（NPs）在生物系统中的作用，近来纳米粒子（NPs）的广泛应用引起了关注。尽管NP可以天然产生，但是工业合成的NP由于它们的高反应性而影响给定生物的代谢。NPs的生物转化涉及不同的过程，包括聚集/团聚以及与生物分子的反应，这将在其毒性中得到反映。几种分析技术，包括电感耦合等离子体质谱法（ICP-MS），已用于表征和定量生物样品中的NP。实际上，除了提供有关NP的形态和浓度的信息之外，基于ICP-MS的平台（例如液相色谱/ ICP-MS，单颗粒ICP-MS，场流分级分离（不对称流场流分级分离）-ICP-MS和激光烧蚀-ICP-MS产生有关分子的元素信息。此外，这些信息与物种分析一起扩大了我们对NP与生物机体之间相互作用的了解。这项研究报告了基于ICP-MS的平台作为评估不同生物样品中NP的工具的贡献，它提供了对NP行为及其在这些生物中的毒性的进一步理解。