ABSTRACT The capability of ozone to reduce the hazardous impact of environmentally persistent antibiotic tiamulin in term of toxicity reduction and enhancement of biodegradability was investigated. Different ozone doses were applied but ozonation was not effective enough to increase the biodegradability of tiamulin in the aqueous phase. The opposite effect was observed in anaerobic digestion experiments, where ozonation as a pretreatment step of antibiotic-contaminated sludge detoxify tiamulin and improves biogas production for 75%. As confirmed by 1H NMR and HPLC-HRMS analyses, the tiamulin molecule completely reacts with ozone at low ozone/COD molar ratio of 0.03, primarily attacking the vinyl double bond with further oxidation of sulfur and nitrogen atom, and gradual decomposition of tiamulin skeleton.

中文翻译：

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臭氧作为抗生素污染废水和污泥的预处理方法

摘要研究了臭氧在降低毒性和增强生物降解性方面降低环境持久性抗生素泰妙菌素的危险影响的能力。应用了不同的臭氧剂量，但臭氧作用不足以提高水相中泰妙菌素的生物降解性。在厌氧消化实验中观察到相反的效果，其中臭氧化作为抗生素污染污泥的预处理步骤可以解毒泰妙菌素，并将沼气产量提高 75%。1H NMR 和 HPLC-HRMS 分析证实，泰妙菌素分子在 0.03 的低臭氧/COD 摩尔比下与臭氧完全反应，主要攻击乙烯基双键，硫和氮原子进一步氧化，泰妙菌素骨架逐渐分解。