当前位置: X-MOL 学术React. Chem. Eng. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ex situ gas generation for lab scale organic synthesis
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2020-02-28 , DOI: 10.1039/c9re00497a
Joachim Demaerel 1, 2, 3, 4 , Cedrick Veryser 1, 2, 3, 4 , Wim M. De Borggraeve 1, 2, 3, 4
Affiliation  

Synthetic organic reactions involving gaseous reagents are frequently avoided in the research lab for practical and safety reasons. Nevertheless, reactive gases often represent convenient building blocks with high potential for atom economy. This review article aims at highlighting ex situ gas generation methods as safe and easily executable procedures for organic synthesis. Especially the advent of two-chamber type reactors has been responsible for the renewed interest in gas–liquid biphasic transformations. With the exemption of carbon monoxide, a discussion is provided on the scientific work from the last decade which employs ex situ generated gaseous reagents, produced on-demand and in a place other than the reaction mixture itself. Features of these protocols which are especially appealing to a laboratory bench-scale context will be underscored, with an emphasis on safety and synthetic diversity allowed by the gas-mediated reactions.

中文翻译:

用于实验室规模有机合成的异位气体生成

由于实用和安全的原因,在研究实验室中经常避免涉及气态试剂的有机合成反应。然而,反应性气体通常是方便的组成部分,具有很高的原子经济潜力。这篇综述文章旨在突出非原位气体生成方法作为有机合成的安全且容易执行的程序。特别是两室型反应器的出现,引起了人们对气液两相转化的新兴趣。除一氧化碳外,还讨论了近十年来在非原位使用的科学工作产生的气态试剂,按需生产,并且在反应混合物本身以外的地方生产。将强调这些规程的特别吸引实验室工作规模的特点,重点是气体介导的反应所允许的安全性和合成多样性。
更新日期:2020-02-28
down
wechat
bug