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Exploiting insect-specific viruses as a novel strategy to control vector-borne disease.
Current Opinion in Insect Science ( IF 5.8 ) Pub Date : 2020-02-28 , DOI: 10.1016/j.cois.2020.02.005
Edward I Patterson 1 , Jandouwe Villinger 2 , Joseph N Muthoni 2 , Lucien Dobel-Ober 1 , Grant L Hughes 1
Affiliation  

Novel insect-specific viruses (ISVs) are being discovered in many important vectors due to advances in sequencing technology and a growing awareness of the virome. Several in vitro and in vivo studies indicate that ISVs are capable of modulating pathogenic arboviruses. In addition, there is growing evidence that both vertical and horizonal transmission strategies maintain ISVs in vector populations. As such there is potential to exploit ISVs for stand-alone vector control strategies and deploying them in synergy with other symbiont control approaches such as Wolbachia-mediated control. However, before the applied potential can be realized, a greater understanding of their basic biology is required, including their species range, ability to be maintained and transmitted in native and non-native vector hosts, and the effect of infection on a range of pathogens.



中文翻译:

利用昆虫特异性病毒作为控制媒介传播疾病的新策略。

由于测序技术的进步和对病毒的认识的提高,在许多重要的载体中都发现了新型昆虫特异性病毒(ISV)。多项体外体内研究表明,ISV能够调节致病性虫媒病毒。此外,越来越多的证据表明,垂直和水平传播策略都可以在媒介种群中维持ISV。因此,有可能将ISV用于独立的媒介控制策略,并与其他共生控制方法(如Wolbachia)协同部署介导的控制。但是,在实现其应用潜力之前,需要对它们的基本生物学有更深入的了解,包括其种类范围,在天然和非天然载体宿主中维持和传播的能力以及感染对多种病原体的影响。

更新日期:2020-02-28
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