Dietary bioactive polyphenols that demonstrate beneficial biological functions including antioxidant, anti-inflammatory, and anticancer activity hold immense promise as effective and safe chemopreventive and chemosensitizing natural anticancer agents. The underlying molecular mechanisms of polyphenols’ multiple effects are complex and these molecules are considered promising targets for chemoprevention and therapy. However, the development of novel personalized targeted chemopreventive and therapeutic strategies is essential for successful therapeutic outcomes. In this review, we highlight the potential of metastasis-associated protein 1 (MTA1)-targeted anticancer and antitumor effects of three dietary stilbenes, namely resveratrol, pterostilbene, and gnetin C, for prostate cancer management. MTA1, an epigenetic reader and master transcriptional regulator, plays a key role in all stages of prostate cancer progression and metastasis. Stilbenes inhibit MTA1 expression, disrupt the MTA1/histone deacetylase complex, modulate MTA1-associated Epi-miRNAs and reduce MTA1-dependent inflammation, cell survival, and metastasis in prostate cancer in vitro and in vivo. Overall, the MTA1-targeted strategies involving dietary stilbenes may be valuable for effective chemoprevention in selected subpopulations of early stage prostate cancer patients and for combinatorial strategies with conventional chemotherapeutic drugs against advanced metastatic prostate cancer.

膳食生物活性多酚表现出有益的生物功能，包括抗氧化、抗炎和抗癌活性，作为有效和安全的化学预防和化学增敏天然抗癌剂具有巨大的前景。多酚多种作用的潜在分子机制很复杂，这些分子被认为是化学预防和治疗的有希望的靶标。然而，开发新型个性化靶向化学预防和治疗策略对于成功的治疗结果至关重要。在这篇综述中，我们强调了三种膳食二苯乙烯（即白藜芦醇、紫檀芪和 gnetin C）针对转移相关蛋白 1 (MTA1) 的抗癌和抗肿瘤作用在前列腺癌治疗中的潜力。 MTA1 是一种表观遗传阅读器和主要转录调节因子，在前列腺癌进展和转移的所有阶段都发挥着关键作用。二苯乙烯类化合物可抑制 MTA1 表达，破坏 MTA1/组蛋白脱乙酰酶复合物，调节 MTA1 相关 Epi-miRNA，并在体外和体内减少前列腺癌中 MTA1 依赖性炎症、细胞存活和转移。总体而言，涉及膳食二苯乙烯的 MTA1 靶向策略可能对于早期前列腺癌患者选定亚群的有效化学预防以及与传统化疗药物针对晚期转移性前列腺癌的组合策略有价值。