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Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement.
Journal of Pharmaceutical and Biomedical Analysis ( IF 3.1 ) Pub Date : 2020-02-29 , DOI: 10.1016/j.jpba.2020.113222 Yufan Gu 1 , Qing Hu 2 , Jian Sun 2 , Hong Yu 2 , Huiqin Pan 2 , Xiaotong Zhao 2 , Shen Ji 1
Journal of Pharmaceutical and Biomedical Analysis ( IF 3.1 ) Pub Date : 2020-02-29 , DOI: 10.1016/j.jpba.2020.113222 Yufan Gu 1 , Qing Hu 2 , Jian Sun 2 , Hong Yu 2 , Huiqin Pan 2 , Xiaotong Zhao 2 , Shen Ji 1
Affiliation
During routine screening of illegal adulterants in health supplements, a novel sildenafil analogue was discovered, and subsequently isolated by recrystallization. Its structure was elucidated by extensive analyses of high resolution mass spectrometry (HRMS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data. The analogue was finally determined as hydroxycarbodenafil, featuring a hydroxyethyl group instead of an ethyl group on piperazine ring in comparison with carbodenafil.
中文翻译:
一种新西地那非类似物羟基卡地那非的分离和鉴定,该类似物在健康补品中被掺假。
在常规筛查健康补品中的非法掺假品期间,发现了一种新型西地那非类似物,随后通过重结晶进行了分离。通过对高分辨率质谱(HRMS),一维(1D)和二维(2D)核磁共振(NMR)数据的广泛分析,阐明了其结构。最终将该类似物确定为羟基卡地那非,与卡本地那非相比,其特征在于羟乙基而不是哌嗪环上的乙基。
更新日期:2020-03-02
中文翻译:
一种新西地那非类似物羟基卡地那非的分离和鉴定,该类似物在健康补品中被掺假。
在常规筛查健康补品中的非法掺假品期间,发现了一种新型西地那非类似物,随后通过重结晶进行了分离。通过对高分辨率质谱(HRMS),一维(1D)和二维(2D)核磁共振(NMR)数据的广泛分析,阐明了其结构。最终将该类似物确定为羟基卡地那非,与卡本地那非相比,其特征在于羟乙基而不是哌嗪环上的乙基。