Background

Invasive fungal infections (IFIs) represent a global issue and affect various patient populations. In recent years, resistant fungal isolates showing increased azole or echinocandin MICs have been reported, and their potential clinical impact has been investigated.

Aims

To provide an update on the epidemiology of resistance among fungi (e.g., Candida spp., Aspergillus spp., and Cryptococcus spp.) and to offer a critical appraisal of the relevant literature regarding the impact of MICs on clinical outcome in patients with IFI.

Sources

PubMed search with relevant keywords along with a personal collection of relevant publications.

Content

Although antifungal resistance has been associated with a poorer response to antifungal therapy in various studies, other factors such as comorbidities, septic shock and source of infection appear to be key determinants affecting the clinical outcome of patients with IFI.

Implications

Future international collaborative studies are required to tease out the relative contribution of in vitro antifungal resistance on patient outcomes, thus enabling the optimization of IFI management.

中文翻译：

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念珠菌，曲霉菌和隐球菌感染的抗真菌药敏试验：MIC对临床医生有用吗？

背景

侵袭性真菌感染（IFI）代表了一个全球性问题，并影响着各种患者人群。近年来，已经报道显示出增加的唑或棘皮菌素MIC的抗性真菌分离物，并且已经对其潜在的临床影响进行了研究。

目的

提供有关真菌（例如念珠菌属，曲霉属和隐球菌属）之间耐药性流行病学的最新信息，并对有关MIC对IFI患者临床预后的影响进行相关文献的评估。

资料来源

在PubMed中搜索相关关键字以及相关出版物的个人收藏。

内容

尽管在各种研究中，抗真菌药耐药性与抗真菌药治疗反应差有关，但其他因素，如合并症，败血性休克和感染源，似乎是影响IFI患者临床结果的关键因素。

含义

需要未来的国际合作研究来阐明体外抗真菌药耐药性对患者预后的相对影响，从而优化IFI管理。