BACKGROUND Cancer care is evolving rapidly, and costs and value of new treatments are frequently debated. Up-to-date evidence on the total cost of cancer is needed to inform policy decisions. This study estimates the cost of cancer in Europe in 2018 and extends a previous analysis for 1995-2014. METHODS Cancer-specific health expenditure were derived from national estimates. Data on cancer drug sales were obtained from IQVIA. The productivity loss from premature mortality was estimated from data from Eurostat and the World Health Organization. Estimates of the productivity loss from morbidity and informal care costs were based on previous studies. FINDINGS The total cost of cancer was €199 billion in Europe (EU-27 plus Iceland, Norway, Switzerland, and the United Kingdom) in 2018. Total costs ranged from €160 per capita in Romania to €578 in Switzerland (after adjustment for price differentials). Health expenditure on cancer care were €103 billion, of which €32 billion were spent on cancer drugs. Informal care costs were €26 billion. The total productivity loss was €70 billion, composed of €50 billion from premature mortality and €20 billion from morbidity. INTERPRETATION Health expenditure on cancer care were of a similar magnitude as the sum of non-health-care costs in 2018. Over the last two decades, health spending on cancer has increased faster than the increase in cancer incidence. The productivity loss from premature mortality has decreased because of reductions in mortality in the working-age population. Trends in informal care costs and productivity loss from morbidity are uncertain because of lack of comparable data.

中文翻译：

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2018年欧洲癌症成本。

背景技术癌症护理正在迅速发展，并且经常争论新疗法的成本和价值。需要有关癌症总费用的最新证据来指导政策决策。这项研究估计了2018年欧洲的癌症成本，并扩展了1995-2014年的先前分析。方法癌症特定的健康支出来自国家估算。有关癌症药物销售的数据是从IQVIA获得的。欧盟统计局和世界卫生组织的数据估计了过早死亡造成的生产力损失。发病率和非正式护理费用对生产力损失的估计是基于以前的研究。发现2018年，欧洲（EU-27加上冰岛，挪威，瑞士和英国）的癌症总费用为1,990亿欧元。总成本从罗马尼亚的人均160欧元到瑞士的578欧元（经价格差异调整后）。癌症护理的卫生支出为1,030亿欧元，其中320亿欧元用于抗癌药物。非正式护理费用为260亿欧元。生产力损失总额为700亿欧元，其中500亿欧元来自过早死亡，200亿欧元来自发病率。解释癌症医疗保健支出与2018年非医疗保健支出之和的数额相似。在过去的二十年中，癌症医疗保健支出的增长速度快于癌症发病率的增长。由于工作年龄人口死亡率的降低，过早死亡造成的生产力损失有所减少。