Abstract Cronobacter sakazakii (C. sakazakii) is a foodborne opportunistic pathogen that can cause life-threatening invasive diseases, such as necrotizing enterocolitis, meningitis, and sepsis in infants. The potential risk of C. sakazakii contamination of powdered infant formula (PIF) is an issue that has attracted considerable attention from manufacturers, regulators, and consumers. C. sakazakii biofilms on the surfaces of equipment and in diverse food-production environments constitute a mode of cell growth that protects the pathogen from hostile environments, and are an important source of persistent contamination of food products. Bacterial biofilms are difficult to remove due to their resistant properties. Conventional cleaning and sterilizing procedures may be insufficient for biofilm control, and may lead to further biofilm development and dispersal. Consequently, novel control strategies are being developed, such as nanotechnology-based delivery systems, interspecies interactions, antimicrobial molecules of microbial origin, natural extracts, and phages. This review focuses on describing the mechanisms underlying the biofilm formation and behavior of C. sakazakii and discussing potential control strategies.

中文翻译：

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食品工业中坂崎克罗诺杆菌生物膜形成和控制策略的洞察

摘要 坂崎克罗诺杆菌 (C. sakazakii) 是一种食源性条件致病菌，可导致危及生命的侵袭性疾病，如婴儿坏死性小肠结肠炎、脑膜炎和败血症。婴儿配方奶粉 (PIF) 被阪崎肠杆菌污染的潜在风险已引起制造商、监管机构和消费者的广泛关注。设备表面和不同食品生产环境中的阪崎肠杆菌生物膜构成了一种细胞生长模式，可保护病原体免受恶劣环境的影响，并且是食品持续污染的重要来源。细菌生物膜由于其耐受性而难以去除。传统的清洁和消毒程序可能不足以控制生物膜，并可能导致进一步的生物膜发展和扩散。因此，正在开发新的控制策略，例如基于纳米技术的传递系统、种间相互作用、微生物来源的抗菌分子、天然提取物和噬菌体。这篇综述重点描述了阪崎肠杆菌生物膜形成和行为的潜在机制，并讨论了潜在的控制策略。