BACKGROUND Hip osteoarthritis (HOA) is the most common hip disorder and a major cause of disability in the adult population, with an estimated prevalence of end-stage disease and total hip replacement. Thus, the diagnosis, prevention, and treatment of the early stages of the disease in young adults are crucial to reduce the incidence of end-stage HOA. The purpose of this study was to determine whether (1) a relationship among the inflammatory status of labrum and synovium collected from patients with femoroacetabular impingement (FAI) would exist; and (2) to investigate the associations among the histopathological features of joint tissues, the pre-operative symptoms and the post-operative outcomes after arthroscopic surgery. METHODS Joint tissues from 21 patients undergoing hip arthroscopy for FAI were collected and their histological and immunohistochemical features were correlated with clinical parameters. RESULTS Synovial mononuclear cell infiltration was observed in 25% of FAI patients, inversely correlated with the hip disability and osteoarthritis outcome score (HOOS) pain and function subscales and with the absolute and relative change in total HOOS. All the labral samples showed some pattern of degeneration and 67% of the samples showed calcium deposits. The total labral score was associated with increased CD68 positive cells in the synovium. The presence of labral calcifications, along with the chondral damage worsened the HOOS post-op symptoms (adjusted R-square = 0.76 p = 0.0001). CONCLUSIONS Our study reveals a relationship between the histologic labral features, the synovial inflammation, and the cartilage condition at the time of FAI. The presence of labral calcifications, along with the cartilage damage and the synovitis negatively affects the post-operative outcomes in patients with FAI.

中文翻译：

---

唇钙化在股骨髋臼撞击中的髋部疼痛和症状中起关键作用。

背景技术髋骨关节炎（HOA）是成人人群中最常见的髋部疾病和残疾的主要原因，其估计的终末期疾病和全髋关节置换的患病率。因此，年轻人的疾病早期诊断，预防和治疗对于降低晚期HOA的发生率至关重要。这项研究的目的是确定（1）从股骨髋臼撞击症（FAI）患者那里收集的唇唇和滑膜的炎症状态之间是否存在关系；（2）研究关节组织手术后关节组织的组织病理学特征与术前症状和术后预后之间的关系。方法收集21例行髋关节镜下FAI的患者的关节组织，并将其组织学和免疫组化特征与临床参数相关联。结果在25％的FAI患者中观察到滑膜单核细胞浸润，与髋关节残疾和骨关节炎预后评分（HOOS）疼痛和功能分量表以及总HOOS的绝对和相对变化呈负相关。所有的唇部样本均表现出一定程度的变性，并且67％的样本均显示出钙沉积。总实验室评分与滑膜中CD68阳性细胞增加有关。实验室钙化的存在以及软骨损伤使HOOS术后症状加重（校正后的R平方= 0.76 p = 0.0001）。结论我们的研究揭示了FAI时组织学唇形特征，滑膜炎症和软骨状况之间的关系。唇钙化以及软骨损伤和滑膜炎的存在对FAI患者的术后结局产生负面影响。