ABSTRACT Lipids and DNAs are two major building blocks of life. Interestingly, by chemically linking these two natural compounds together, synthetic lipid-DNA conjugates exhibit several attractive features for cell membrane studies. These lipid-DNA conjugates are amphiphilic macromolecules combining the cell membrane insertion capability of lipids with the properties of DNAs in precise hybridization and programmability. These supramolecular conjugates have demonstrated exciting applications from generating cell membrane nanopores to transmembrane cargo deliveries, and from analyzing cell membrane events to tissue engineering. In this review, we will discuss the design, structures, and biological applications of lipid-DNA conjugates, with an emphasis on their functions on live cell membranes. We expect, in the near future, significant advancement in our ability to understand, control, and apply these cell membrane-modified lipid-DNA conjugates. Graphical abstract

中文翻译：

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用于细胞膜修饰、分析和调节的脂质-DNA 偶联物

摘要 脂质和 DNA 是生命的两大基石。有趣的是，通过将这两种天然化合物化学连接在一起，合成脂质-DNA 偶联物在细胞膜研究中表现出几个有吸引力的特征。这些脂质-DNA 偶联物是两亲性大分子，结合了脂质的细胞膜插入能力和 DNA 在精确杂交和可编程性方面的特性。从产生细胞膜纳米孔到跨膜货物输送，以及从分析细胞膜事件到组织工程，这些超分子偶联物已经展示了令人兴奋的应用。在这篇综述中，我们将讨论脂质-DNA 偶联物的设计、结构和生物学应用，重点是它们在活细胞膜上的功能。我们预计，在不久的将来，我们理解、控制和应用这些细胞膜修饰的脂质-DNA 偶联物的能力有了显着进步。图形概要