ABSTRACT The ability to bind and detect analytes with high levels of selectivity, sensitivity and broad applicability for a variety of analytes is an essential goal, with applications in public health and environmental remediation. Methods to achieve effective binding and detection include electrochemical, and spectroscopic methods. The use of supramolecular chemistry to accomplish such detection, by binding a target in a host and transducing that binding into a measurable signal, has advantages, including tunability of the sensor and the ability to rationally design hosts through an understanding of non-covalent interactions. Reported herein is the design and use of pillar[5]arenes to accomplish precisely such detection. Water-soluble pillar[5]arenes containing 10 cationic linker arms on their periphery bound toxicants in their hydrophobic cores with association constants of 105–106M−1. With the use of cationic exchange resins, the pillar[5]arene hosts were removed from solution with their encapsulated guests, allowing for effective toxicant removal. GraphicalAbstract

中文翻译：

---

一种用于从水介质中结合和去除有机毒物的聚阳离子柱[5]芳烃

摘要 以高选择性、灵敏度和广泛适用性对各种分析物进行结合和检测分析物的能力是一个基本目标，可应用于公共卫生和环境修复。实现有效结合和检测的方法包括电化学和光谱方法。使用超分子化学来完成这种检测，通过在宿主中结合目标并将该结合转换为可测量的信号，具有优势，包括传感器的可调性和通过理解非共价相互作用合理设计宿主的能力。本文报道了柱[5]芳烃的设计和使用以精确完成此类检测。水溶性柱[5]芳烃在其外围含有10个阳离子连接臂，在其疏水核中结合有毒物质，结合常数为105-106M-1。通过使用阳离子交换树脂，柱[5]芳烃主体与其封装的客体一起从溶液中去除，从而有效去除毒物。图形概要