ABSTRACT This account describes the latest developments in the field of chirality-assisted synthesis (CAS). CAS has emerged as a versatile method to control the shapes of π-conjugated macromolecules and supramolecular assemblies. With CAS, the sequence and chirality of the monomeric building blocks dictates the shape and functions of the resulting macromolecules in a programmable fashion. Supramolecular materials with special functions, e.g. the ability to encapsulate macrocycles, can be created with CAS. CAS has been utilized to synthesize a variety of shape-defined nanoscale structures, including polyaromatic strips, helices, molecular claws, and very large hydrogen-bonded closed-shell capsules. Applications, challenges, and future directions of the growing CAS field are discussed in light of the unique shape-control abilities CAS has to offer. Graphical Abstract

中文翻译：

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通过手性辅助合成精确控制线性和支化条带的分子形状

摘要 该帐户描述了手性辅助合成 (CAS) 领域的最新进展。CAS 已成为控制 π 共轭大分子和超分子组装体形状的通用方法。使用 CAS，单体构建块的序列和手性以可编程的方式决定了所得大分子的形状和功能。具有特殊功能的超分子材料，例如封装大环的能力，可以用 CAS 制造。CAS 已被用于合成各种形状定义的纳米级结构，包括多环芳烃条、螺旋、分子爪和非常大的氢键封闭壳胶囊。根据 CAS 必须提供的独特形状控制能力，讨论了不断发展的 CAS 领域的应用、挑战和未来方向。