ABSTRACT Two new binuclear Cu(II) complexes Cu2L4(DMS)2 (1) and Cu2L4(3BrPy)2 (2) where L = para-chlorophenyl acetate, DMS = dimethylsulfoxide and 3BrPy = 3-bromopyridine have been synthesised and characterised using FT-IR, single crystal XRD analysis, absorption and conductance studies. In both the complexes copper(II) ion lies in distorted square pyramidal geometry where the apical position is occupied by pyridine in monodentate fashion while the equatorial positions are occupied by four carboxylate ligands in bidentate coordination mode. The supramolecular structures of the complexes arise primarily as a result of C–H…O and H–C…H types of interactions and are different owing to the different apical ligands. The DNA-binding activity of the complexes has been studied through absorption spectroscopy, viscometry and competitive ethidium bromide displacement techniques. These techniques indicated a mixed electrostatic and intercalative mode of interaction with DNA-binding constant values Kb of 1.98 × 104 M−1 and 2.86 × 104 M−1 for complexes 1 and 2, respectively. These activities represent the preliminary biological relevance of the synthesised complexes. Graphical abstract

中文翻译：

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三元桨轮铜 (II) 复合物：合成、结构解析、DNA 结合、抗氧化和电导研究

摘要 合成了两种新的双核 Cu(II) 配合物 Cu2L4(DMS)2 (1) 和 Cu2L4(3BrPy)2 (2)，其中 L = 对氯苯乙酸酯，DMS = 二甲基亚砜和 3BrPy = 3-溴吡啶已使用 FT 合成和表征-IR、单晶 XRD 分析、吸收和电导研究。在这两种配合物中，铜 (II) 离子都处于扭曲的四角锥几何形状中，其中顶端位置被单齿形式的吡啶占据，而赤道位置则被四个以双齿配位方式的羧酸配体占据。复合物的超分子结构主要是由于 C–H…O 和 H–C…H 类型的相互作用而产生的，并且由于顶端配体不同而不同。通过吸收光谱研究了复合物的 DNA 结合活性，粘度测定法和竞争性溴化乙锭置换技术。这些技术表明，复合物 1 和 2 的 DNA 结合常数值 Kb 分别为 1.98 × 104 M-1 和 2.86 × 104 M-1，具有混合静电和嵌入相互作用模式。这些活性代表了合成复合物的初步生物学相关性。图形概要