Although a wide range of separation techniques are used for preparation of radionuclide generators, the low pressure column chromatography technique has dominated the field significantly. In this technique, the adsorbent remains at the ‘heart’ of the system holding the parent radionuclide and this represents the cornerstone for its success. Although this strategy constitutes a successful paradigm for the preparation of radionuclide generators, the limited capacity of conventional adsorbents restricts their applicability for preparation of high activity generators while using low specific activity parent radionuclides. In this direction, the scope of using nanostructured materials in radionuclide generators represents an active area of research. This review is a comprehensive account of the latest research and development activities on the use of nanomaterial-based adsorbents in the development of radionuclide generators. It conveys the importance of nanomaterial-based-adsorbents, which can change the paradigm of radionuclide generator technology and stimulate further interest in the scientific community towards this field.

尽管使用了多种分离技术来制备放射性核素发生器，但低压柱色谱技术已在该领域占据了主导地位。在这种技术中，吸附剂保留在持有母体放射性核素的系统的“心脏”处，这是其成功的基石。尽管此策略构成了制备放射性核素发生器的成功范例，但常规吸附剂的容量有限，限制了其在使用低比活度母体放射性核素的同时制备高活性发生器的适用性。在这个方向上，在放射性核素发生器中使用纳米结构材料的范围代表了一个活跃的研究领域。本文是对放射性核素发生器开发中使用纳米材料基吸附剂的最新研究和开发活动的全面介绍。它传达了基于纳米材料的吸附剂的重要性，它可以改变放射性核素发生器技术的范式，并激发科学界对该领域的进一步兴趣。