The main objective of this study was the catalytic preparation 5-aryl-1,3,4,5-tetrahydro2H-pyrano[2,3-d]pyrimidine-6-carbonitrile derivatives using liquid glass as a catalyst. All reactions were performed in water under reflux conditions. As a further objective, the procedure was investigated using high-speed ball milling (HSBM) techniques. The effects of liquid glass composition and addition of metal oxide impurities were investigated. Recently, compounds containing at least one core moiety of pyrano[2,3-d]pyrimidine have received considerable attention in synthetic organic chemistry because of their potential as drugs and bioactive compounds. Pyrano[2,3-d]pyrimidines have attracted interest in medicine as antitumor, anti-hypertensive, antibacterial and antileishmanial drugs. Pyrano[2,3-d]pyrimidines have been produced by a number of methods. A complete review of the synthetic procedures and discussion about these compounds is available. Liquid glass with the formula of Na2(SiO2)nO is an aqueous solution of sodium silicate which can be easily prepared from the reaction of NaOH (25%) with SiO2 or by melting sodium carbonate with silicon dioxide. Liquid glass has been used as a binding and coating agent for decades. Liquid glass is a non-toxic, heat durable, stable, low-cost and environmentally friendly material with a strong basic nature. Moreover, liquid glasses show unique chemical properties because their surface charge can be modified and their viscosity can be regulated. Unfortunately their application in organic synthesis has been neglected. This has encouraged us to continue our investigations on the catalytic activity of liquid glass for the synthesis of a variety of pyrano[2,3-d]pyrimidine derivatives via

中文翻译：

---

液态玻璃组成对吡喃并[2,3-d]嘧啶衍生物催化制备的影响

本研究的主要目的是使用液态玻璃作为催化剂催化制备5-芳基-1,3,4,5-四氢2H-吡喃并[2,3-d]嘧啶-6-腈衍生物。所有反应均在水中回流条件下进行。作为进一步的目标，使用高速球磨 (HSBM) 技术研究了该过程。研究了液态玻璃成分和添加金属氧化物杂质的影响。最近，含有至少一个吡喃并[2,3-d]嘧啶核心部分的化合物因其作为药物和生物活性化合物的潜力而在合成有机化学中受到了相当大的关注。吡喃并[2,3-d]嘧啶作为抗肿瘤、抗高血压、抗菌和抗利什曼病药物在医学上引起了人们的兴趣。吡喃并[2,3-d]嘧啶已通过多种方法生产。可以获得对合成程序的完整审查和关于这些化合物的讨论。分子式为 Na2(SiO2)nO 的液态玻璃是一种硅酸钠水溶液，可通过 NaOH (25%) 与 SiO2 反应或通过将碳酸钠与二氧化硅熔化来制备。数十年来，液态玻璃一直被用作粘合剂和涂层剂。液态玻璃是一种无毒、耐热、稳定、低成本、环保的材料，具有很强的碱性。此外，液体玻璃显示出独特的化学性质，因为它们的表面电荷可以改变，并且它们的粘度可以调节。不幸的是，它们在有机合成中的应用一直被忽视。这鼓励我们继续研究液态玻璃对合成各种吡喃的催化活性[2,