The development of an atom-economical approach for the efficient construction of diversely functionalized molecules from easily accessible starting materials is always a special issue for synthetic organic chemists. The 4-substituted 1,4-dihydropyridine (1,4-DHP) nucleus is a rich source of biological molecules which are useful as antihypertensive, vasodilator, antitherosclerotic, antitumor, geroprotective and antidiabetic agents. These compounds also have activities as neuroprotectants and as platelet anti-aggregants. They have cerebral antischaemic activity in the treatment of Alzheimer’s disease and chemosensitizer behavior in tumor therapy. The valuable cardiovascular agents nifepidin, felodipine and amlodipine belong to this category of compounds, and they play important roles in hypertension treatments. They have shown usefulness in the treatment of angina pectoris and other cardiovascular diseases. The best methods for the synthesis of polyhydroquinolines are multicomponent reactions. These advantageous reactions are in agreement with green chemistry principles such as atom economy and resource-effectiveness bond-forming efficiency. There are many approaches in the literature for the preparation of polyhydroquinolines. They include the use of such catalysts as Co3O4-CNTs, 18 Ni0.35Cu0.25Zn0.4Fe2O4 MNPs, ceric ammonium nitrate, cetyltrimethylammonium bromide, MCM-41, p-TSA, scolecite, hafnium(IV)bis(perfluorooctanesulfonyl)imide, PPA-SiO2, 26

中文翻译：

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纳米Fe3O4@SiO2负载ZnCl2催化一锅法合成聚氢喹啉

开发一种原子经济的方法，用于从容易获得的起始材料中有效构建多种功能化的分子，一直是合成有机化学家的一个特殊问题。4-取代的 1,4-二氢吡啶 (1,4-DHP) 核是生物分子的丰富来源，可用作抗高血压剂、血管扩张剂、抗动脉粥样硬化剂、抗肿瘤剂、老年保护剂和抗糖尿病剂。这些化合物还具有作为神经保护剂和作为血小板抗聚集剂的活性。它们在治疗阿尔茨海默病中具有脑抗缺血活性，在肿瘤治疗中具有化学增敏作用。有价值的心血管药物硝苯吡啶、非洛地平和氨氯地平属于此类化合物，它们在高血压治疗中发挥重要作用。它们在治疗心绞痛和其他心血管疾病方面显示出有用。合成聚氢喹啉的最佳方法是多组分反应。这些有利的反应符合绿色化学原理，如原子经济性和资源效率成键效率。文献中有许多制备聚氢喹啉的方法。它们包括使用此类催化剂，如 Co3O4-CNT、18 Ni0.35Cu0.25Zn0.4Fe2O4 MNP、硝酸铈铵、十六烷基三甲基溴化铵、MCM-41、p-TSA、solecite、铪（IV）双（全氟辛烷磺酰）亚胺、P -SiO2, 26 这些有利的反应符合绿色化学原理，如原子经济性和资源效率成键效率。文献中有许多制备聚氢喹啉的方法。它们包括使用此类催化剂，如 Co3O4-CNT、18 Ni0.35Cu0.25Zn0.4Fe2O4 MNP、硝酸铈铵、十六烷基三甲基溴化铵、MCM-41、p-TSA、solecite、铪（IV）双（全氟辛烷磺酰）亚胺、P -SiO2, 26 这些有利的反应符合绿色化学原理，如原子经济性和资源效率成键效率。文献中有许多制备聚氢喹啉的方法。它们包括使用此类催化剂，如 Co3O4-CNT、18 Ni0.35Cu0.25Zn0.4Fe2O4 MNP、硝酸铈铵、十六烷基三甲基溴化铵、MCM-41、p-TSA、solecite、铪（IV）双（全氟辛烷磺酰）亚胺、P -SiO2, 26