A random terpolymer of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) was synthesized from L-lactide, glycolide and ε-caprolactone. The in-vitro hydrolytic degradation behavior of the PLLGC terpolymer was investigated as a function of the degradation time; the results showed that the degradation rate of PLLGC was lower than that of PLGA due to a reduction in the acidic degradation products. Therefore, we suggest the degradation rate of the PLGA could be controllable by introduction of ε-caprolactone into the PLGA martrix, while the physical properties (mechanical, etc.) were superior to PLGA.

中文翻译：

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聚（L-丙交酯-乙交酯-ε-己内酯）三元共聚物的制备及体外降解行为

由L-丙交酯，乙交酯和ε-己内酯合成了聚（L-丙交酯-乙交酯-ε-己内酯）无规三元共聚物。研究了PLLGC三元共聚物的体外水解降解行为与降解时间的关系。结果表明，由于酸性降解产物的减少，PLLGC的降解率低于PLGA。因此，我们认为通过将ε-己内酯引入PLGA基质可以控制PLGA的降解速率，而物理性能（机械等）优于PLGA。