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Preparation and In-vitro Degradation Behavior of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Terpolymer
Journal of Macromolecular Science Part B-Physics ( IF 1.2 ) Pub Date : 2019-04-20 , DOI: 10.1080/00222348.2019.1601809
Wei Wu 1 , Zhihua Zhou 1, 2, 3, 4 , Wenjuan Liu 2 , Yunhui Zhao 1 , Yanmin Zhao 1 , Tianlong Huang 5 , Xiaofei Li 1 , Jianjun Fang 1
Affiliation  

A random terpolymer of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) was synthesized from L-lactide, glycolide and ε-caprolactone. The in-vitro hydrolytic degradation behavior of the PLLGC terpolymer was investigated as a function of the degradation time; the results showed that the degradation rate of PLLGC was lower than that of PLGA due to a reduction in the acidic degradation products. Therefore, we suggest the degradation rate of the PLGA could be controllable by introduction of ε-caprolactone into the PLGA martrix, while the physical properties (mechanical, etc.) were superior to PLGA.



中文翻译:

聚(L-丙交酯-乙交酯-ε-己内酯)三元共聚物的制备及体外降解行为

由L-丙交酯,乙交酯和ε-己内酯合成了聚(L-丙交酯-乙交酯-ε-己内酯)无规三元共聚物。研究了PLLGC三元共聚物的体外水解降解行为与降解时间的关系。结果表明,由于酸性降解产物的减少,PLLGC的降解率低于PLGA。因此,我们认为通过将ε-己内酯引入PLGA基质可以控制PLGA的降解速率,而物理性能(机械等)优于PLGA。

更新日期:2019-04-20
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