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Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.
Obesity ( IF 4.2 ) Pub Date : 2020-02-28 , DOI: 10.1002/oby.22759 Ziad S Mahmassani 1 , Paul T Reidy 1 , Alec I McKenzie 1 , Jonathan J Petrocelli 1 , O'Connor Matthews 1 , Naomi M de Hart 2 , Patrick J Ferrara 2 , Ryan M O'Connell 3 , Katsuhiko Funai 1 , Micah J Drummond 1
Obesity ( IF 4.2 ) Pub Date : 2020-02-28 , DOI: 10.1002/oby.22759 Ziad S Mahmassani 1 , Paul T Reidy 1 , Alec I McKenzie 1 , Jonathan J Petrocelli 1 , O'Connor Matthews 1 , Naomi M de Hart 2 , Patrick J Ferrara 2 , Ryan M O'Connell 3 , Katsuhiko Funai 1 , Micah J Drummond 1
Affiliation
Inactivity and inflammation are linked to obesity and insulin resistance. It was hypothesized that MyD88 (mediates inflammation) knockout from muscle (MusMyD88−/−) would prevent, whereas miR146a−/− (MyD88 inhibitor) would exacerbate, inactivity‐induced metabolic disturbances.
中文翻译：
骨骼肌中 MyD88 的缺失可以保护雌性小鼠免受缺乏活动引起的肥胖和胰岛素抵抗。
缺乏活动和炎症与肥胖和胰岛素抵抗有关。据推测，从肌肉中敲除 MyD88（介导炎症）（MusMyD88 −/− ）可以预防，而 miR146a −/− （MyD88 抑制剂）则会加剧不活动引起的代谢紊乱。
更新日期：2020-02-28
中文翻译：
骨骼肌中 MyD88 的缺失可以保护雌性小鼠免受缺乏活动引起的肥胖和胰岛素抵抗。
缺乏活动和炎症与肥胖和胰岛素抵抗有关。据推测，从肌肉中敲除 MyD88（介导炎症）（MusMyD88 −/− ）可以预防，而 miR146a −/− （MyD88 抑制剂）则会加剧不活动引起的代谢紊乱。
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