Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established treatment after the failure to standard of care based on steroids and vigabatrin. Converging lines of evidence indicating a role of NR2B subunits of the N‐methyl‐D‐aspartate (NMDA) receptor on the onset of spams in ISS patients, prompted us to test radiprodil, a negative allosteric NR2B modulator in preclinical seizure models and in infants with ISS.

中文翻译：

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Radiprodil是一种NR2B阴性变构调节剂，在婴儿痉挛综合征中从板凳到床边。

婴儿痉挛综合征（ISS）是一种癫痫性脑病，在基于类固醇和vigabatrin的护理标准失败后，未建立治疗方案。越来越多的证据表明N-甲基-D-天门冬氨酸（NMDA）受体的NR2B亚基在ISS患者垃圾邮件发作中的作用，促使我们在临床前癫痫发作模型和婴儿中测试radiprodil（一种负变构NR2B调节剂）与国际空间站。