当前位置: X-MOL 学术Proteomics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Proteomic Investigation on Anopheles gambiae in Burkina Faso Related to Insecticide Pressures from Different Climatic Regions.
Proteomics ( IF 3.4 ) Pub Date : 2020-04-02 , DOI: 10.1002/pmic.201900400
Abdou Azaque Zouré 1, 2 , Laurent Serteyn 2 , Zéphirin Somda 3 , Athanase Badolo 3 , Frédéric Francis 2
Affiliation  

In Sub-Saharan Africa, An. gambiae sensu lato (s.l.) Giles 190, largely contributes to malaria transmission. Therefore, the authors carry out a proteomic analysis to compare its metabolic state, depending on different pesticide pressures by selecting areas with/without cotton crops. The proteomes data are available via ProteomeXchange with identifier PXD016300. From a total of 1.182 identified proteins, 648 are retained for further statistical analysis and are attributed to biological functions, the most important of which being energy metabolism (120 proteins) followed by translation-biogenesis (74), cytoskeleton (71), stress response (62), biosynthetic process (60), signalling (44), cellular respiration (38), cell redox homeostasis (25), DNA processing (17), pheromone binding (10), protein folding (9), RNA processing (9), other proteins (26) and unknown functions (83). In the Sudano-Sahelian region, 421 (91.3%) proteins are found in samples from areas both with and without cotton crops. By contrast, in the Sahelian region, only 271 (55.0%) are common to both crop areas, and 233 proteins are up-regulated from the cotton area. The focus is placed on proteins with putative roles in insecticide resistance, according to literature. This study provides the first whole-body proteomic characterisation of An. gambiae s.l. in Burkina Faso, as a framework to strengthen vector control strategies.

中文翻译:

布基纳法索冈比亚按蚊的蛋白质组学研究与不同气候区域的杀虫剂压力相关。

在撒哈拉以南非洲,冈比亚sensu lato(sl)Giles 190,在很大程度上促进了疟疾的传播。因此,作者通过选择有无棉花的地区,根据不同的农药压力,进行了蛋白质组学分析,以比较其代谢状态。蛋白质组数据可通过ProteomeXchange获得,其标识符为PXD016300。在总共1.182种已鉴定的蛋白质中,保留了648种以进行进一步的统计分析,这归因于生物学功能,其中最重要的是能量代谢(120种蛋白质),其次是翻译生物发生(74),细胞骨架(71),应激反应(62),生物合成过程(60),信号传导(44),细胞呼吸(38),细胞氧化还原稳态(25),DNA处理(17),信息素结合(10),蛋白质折叠(9),RNA处理(9) ),其他蛋白质(26)和未知功能(83)。在Sudano-Sahelian地区,有和没有棉花作物的地区的样品中共发现421种蛋白(91.3%)。相比之下,在萨赫勒地区,两个作物区域共有271个(55.0%)是共有的,而棉花区域则有233种蛋白质上调。根据文献,重点放在在杀虫剂抗性方面具有假定作用的蛋白质上。这项研究提供了An的第一个全身蛋白质组学表征。布基纳法索的冈比亚sl,作为加强病媒控制策略的框架。根据文献,重点放在在杀虫剂抗性方面具有假定作用的蛋白质上。这项研究提供了An的第一个全身蛋白质组学表征。布基纳法索的冈比亚sl,作为加强病媒控制策略的框架。根据文献,重点放在在杀虫剂抗性方面具有假定作用的蛋白质上。这项研究提供了An的第一个全身蛋白质组学表征。布基纳法索的冈比亚sl,作为加强病媒控制策略的框架。
更新日期:2020-04-03
down
wechat
bug