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From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-02-28 , DOI: 10.1002/adhm.201901552
Xuan Mu 1 , Vincent Fitzpatrick 1 , David L Kaplan 1
Affiliation  

Silk spinning offers an evolution‐based manufacturing strategy for industrial polymer manufacturing, yet remains largely inaccessible as the manufacturing mechanisms in biological and synthetic systems, especially at the molecular level, are fundamentally different. The appealing characteristics of silk spinning include the sustainable sourcing of the protein material, the all‐aqueous processing into fibers, and the unique material properties of silks in various formats. Substantial progress has been made to mimic silk spinning in artificial manufacturing processes, despite the gap between natural and artificial systems. This report emphasizes the universal spinning conditions utilized by both spiders and silkworms to generate silk fibers in nature, as a scientific and technical framework for directing molecular assembly into high‐performance structures. The preparation of regenerated silk feedstocks and mimicking native spinning conditions in artificial manufacturing are discussed, as is progress and challenges in fiber spinning and 3D printing of silk‐composites. Silk spinning is a biomimetic model for advanced and sustainable artificial polymer manufacturing, offering benefits in biomedical applications for tissue scaffolds and implantable devices.

中文翻译:


从丝纺到 3D 打印:使用定向分层分子组装进行聚合物制造。



丝纺为工业聚合物制造提供了一种基于进化的制造策略,但由于生物和合成系统中的制造机制(尤其是在分子水平上)根本不同,因此在很大程度上仍然难以实现。丝纺的吸引人的特点包括蛋白质材料的可持续来源、纤维的全水加工以及各种形式的丝绸的独特材料特性。尽管自然系统和人工系统之间存在差距,但在人工制造过程中模拟丝纺已经取得了实质性进展。该报告强调了蜘蛛和蚕在自然界中产生丝纤维的通用纺丝条件,作为指导分子组装成高性能结构的科学和技术框架。讨论了人工制造中再生丝原料的制备和模拟天然纺丝条件,以及纤维纺丝和丝复合材料 3D 打印的进展和挑战。丝纺是一种先进且可持续的人造聚合物制造的仿生模型,为组织支架和可植入设备的生物医学应用带来好处。
更新日期:2020-02-28
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