A catalytic synthesis of dihydrofuran‐3(2H)‐imine skeletons from isocyanides, terminal alkynes, and oxiranes,Journal of Heterocyclic Chemistry

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A catalytic synthesis of dihydrofuran‐3(2H)‐imine skeletons from isocyanides, terminal alkynes, and oxiranes
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-02-28 , DOI: 10.1002/jhet.3918
Alireza Samzadeh‐Kermani ₁ , Marjan Poorhabibi‐Zarandi ₁

Affiliation

In this catalytic multicomponent reaction, the nucleophilicity of terminal alkynes and isocyanides towards oxiranes has been explored. The reaction outcome depends highly on solvent, bases, and catalysts sources. An array of terminal alkynes, isocyanides, and oxiranes has been examined to explore the of this transformation. The reactions proceeded through S_N2 path and in regioselective manner.

中文翻译：

由异氰酸酯，末端炔烃和环氧乙烷催化合成二氢呋喃-3（2H）-亚胺骨架

在该催化多组分反应中，已经研究了末端炔烃和异氰酸酯对环氧乙烷的亲核性。反应结果高度取决于溶剂，碱和催化剂来源。已经研究了一系列末端炔烃，异氰化物和环氧乙烷，以探索这种转变的过程。反应通过S _N 2路径并以区域选择性方式进行。

更新日期：2020-02-28

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