A Cascade synthesis of 11bH‐Imidazo[1,2‐c]isoquinolino[2,1‐a]quinazoline derivatives catalyzed by AgOTf,Journal of Heterocyclic Chemistry

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A Cascade synthesis of 11bH‐Imidazo[1,2‐c]isoquinolino[2,1‐a]quinazoline derivatives catalyzed by AgOTf
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-02-27 , DOI: 10.1002/jhet.3940
Hao Wu ₁ , Yi‐Chun Wang ₁ , Tuan‐Jie Li ₁ , Jian‐Quan Liu ₁ , Xiang‐Shan Wang ₁

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A cascade reaction of 2‐alkynylbenzaldehydes and 2‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)aniline was treated in DMF catalyzed by AgOTf leading to 6,13,14‐triaryl‐11bH‐imidazo[1,2‐c] isoquinolino[2,1‐a]quinazolines in high yields. This Domino reaction included condensation, cyclization, and acetylenic hydroamination under mild conditions to build fused pentacyclic heterocycle with three new bonds and two new rings.

中文翻译：

AgOTf催化级联合成11bH-咪唑并[1,2-c]异喹啉并[2,1-a]喹唑啉衍生物

2- alkynylbenzaldehydes和2-（4,5-二苯基-1-甲级联反应ħ -咪唑-2-基）苯胺在DMF处理催化通过的AgOTf导致6,13,14三芳基11 BH咪唑并[1,2 ，2− c ]异喹啉代[2,1− a ]喹唑啉，高产。该多米诺反应包括在温和条件下的缩合，环化和炔属加氢胺化反应，以形成具有三个新键和两个新环的稠合五环杂环。

更新日期：2020-02-27

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