Advanced Manufacturing of Patient‐Specific Occluders for the Left Atrial Appendage with Minimally Invasive Delivery,Advanced Engineering Materials

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Advanced Manufacturing of Patient‐Specific Occluders for the Left Atrial Appendage with Minimally Invasive Delivery
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2020-03-29 , DOI: 10.1002/adem.201901074
Seyedhamidreza Alaie _{1,

2,

3} , Sanlin S. Robinson _{1,

2} , Amir Ali Amiri Moghadam _{1,

2,

4} , Jordyn Augé _{1,

2} , Alexandre Caprio _{1,

2} , Kranthi Kolli _{1,

2} , Subhi J. Al'Aref _{1,

2} , James K. Min _{1,

2} , Bobak Mosadegh _{1,

2} , Simon Dunham _{1,

2}

Affiliation

A novel method for the rapid prototyping of personalized inflatable left atrial appendage occluders, suitable for minimally invasive delivery, is demonstrated. The method allows for the design, fabrication, and quantitative testing of implants based on an individual's computed tomography (CT) scan. The performance of a left atrial appendage occluder by characterizing its ability to anchor, prevent leaks, and not obstruct the left atrium is reported on. The design of the occluder by varying features such as size, inflation fluids, and surface patterns is optimized. The implant, and its delivery via a minimally invasive catheter, is demonstrated in a 3D‐printed left atrial model. Herein, the way for leveraging advanced manufacturing and imaging technologies for the development of personalized intracardiac implants for transcatheter delivery is described.

中文翻译：

先进的患者专用封堵器，用于左心耳附件，并且微创分娩最小

展示了一种适用于微创输送的个性化可充气左心耳封堵器快速原型制作的新方法。该方法允许基于个人的计算机断层扫描（CT）扫描进行植入物的设计，制造和定量测试。据报道，通过表征左心耳封堵器的锚定，防止渗漏和不阻塞左心房的能力，其性能。通过改变特征（例如尺寸，膨胀流体和表面图案）来优化封堵器的设计。在3D打印的左心房模型中演示了植入物及其通过微创导管的递送。在这里

更新日期：2020-03-29

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