Poly (lactate‐co‐glycolate) (PLGA) is a typical biocompatible and biodegradable synthetic polymer. The addition of TiO₂ nanoparticles has shown to improve compressive modulus of PLGA scaffolds and reduced fast degradation. A novel method has been applied to fabricate PLGA/TiO₂ scaffolds without using any inorganic solvent, with aim of improving the biocompatibility, macroscale morphology, and well inter‐connected pores efficacy: Air–Liquid Foaming. Field Emission Scanning Electron Microscopy (FESEM) revealed an increase in interconnected porosity of up to 98%. As well the compressive testing showed enhancement in modulus. Bioactivity and in vitro degradation were studied with immersion of scaffolds in Simulated Body Fluid (SBF) and incubation in Phosphate Buffered Saline (PBS), respectively. Formation of apatite layer corroborated the bioactivity after soaking in SBF. Degradation rate of scaffolds was increased with excessive addition of TiO₂ contents withal. The in vitro cultured human‐like MG63 ostoblast cells showed attachment, proliferation, and nontoxcitiy in contact, using MTT assay [3‐(4, 5‐Dimethylthiazol‐2‐yl)‐2, 5‐Diphenyltetrazolium Bromide]. According to the results, the novel method utilized in this study generated porous viable tissue without using any inorganic solvent or porogen can be a promising candidate in further treatment of orthopedic patients effectively.

中文翻译：

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生产用于组织工程的可生物降解和生物活性 PLGA/TiO2 纳米复合支架的新途径：气液发泡。

聚（乳酸-乙醇酸共聚物）（PLGA）是一种典型的生物相容性和可生物降解的合成聚合物。TiO ₂纳米颗粒的添加已表明可提高PLGA 支架的压缩模量并减少快速降解。一种新方法已用于制备PLGA/TiO ₂不使用任何无机溶剂的支架，旨在提高生物相容性、宏观形态和良好互连的孔隙功效：气液发泡。场发射扫描电子显微镜 (FESEM) 显示互连孔隙率增加了 98%。压缩测试也显示模量增加。分别通过将支架浸入模拟体液 (SBF) 和在磷酸盐缓冲盐水 (PBS) 中孵育来研究生物活性和体外降解。磷灰石层的形成证实了在 SBF 中浸泡后的生物活性。过量添加TiO _{2 会}增加支架的降解率内容。体外培养的类人 MG63 成骨细胞显示附着、增殖和接触无毒，使用 MTT 测定 [3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium Bromide]。根据结果​​，本研究中使用的新方法在不使用任何无机溶剂或致孔剂的情况下生成多孔活组织可以成为有效进一步治疗骨科患者的有希望的候选者。