Copper‐Catalyzed Synthesis of Trinuclear N‐Fused Hybrid Scaffolds by Double C(sp2)–N Bond Formation between 2‐(2‐Bromoaryl)indoles and 2‐Aminoazoles,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper‐Catalyzed Synthesis of Trinuclear N‐Fused Hybrid Scaffolds by Double C(sp2)–N Bond Formation between 2‐(2‐Bromoaryl)indoles and 2‐Aminoazoles
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-02-27 , DOI: 10.1002/ejoc.202000238
Thi Duyen Diep ₁ , Pham Duy Quang Dao ₁ , Son Long Ho ₁ , Chan Sik Cho ₁

Affiliation

A promising synthetic method for indole‐quinazoline‐benzimidazole and indole‐quinazoline‐imidazole trinuclear N‐fused hybrid scaffolds has been developed by copper‐catalyzed C(sp²)‐N coupling and cyclization of 2‐(2‐bromoaryl)indoles with 2‐aminoazoles as new building blocks. Further challenges on the construction of polynuclear N‐fused hybrid scaffolds using 2‐aminoazoles are expected.

中文翻译：

铜催化的2-（2-溴代芳基）吲哚和2-氨基唑之间双C（sp2）-N键形成的三核N杂合支架的铜催化合成。

通过铜催化的C（sp ²）-N偶联和环化2-（2-溴代芳基）吲哚与2的相互作用，开发了一种有前途的吲哚-喹唑啉-苯并咪唑和吲哚-喹唑啉-咪唑三核氮杂合支架的合成方法氨基唑类是新的组成部分。预计使用2-氨基唑类化合物构建多核N融合杂种支架将面临更多挑战。

更新日期：2020-02-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11