Aptamer-functionalized nanomaterials for biological applications,Materials Chemistry Frontiers

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Aptamer-functionalized nanomaterials for biological applications
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-02-28 , DOI: 10.1039/c9qm00779b
Qiaoli Ren _{1,

2,

3,

4} , Lu Ga _{4,

5,

6,

7} , Zhili Lu _{8,

9,

10,

11} , Jun Ai _{1,

2,

3,

4} , Tie Wang _{4,

12,

13,

14,

15}

Affiliation

College of Chemistry and Environmental Science
Inner Mongolia Normal University
Hohhot 010022
People's Republic of China
College of Pharmacy
Inner Mongolia Medical University
Hohhot 010110
Key Laboratory of Materials Processing and Mold
Ministry of Education
Zhengzhou Universit
P. R. China
Beijing National Laboratory for Molecular Sciences
Key Laboratory of Analytical Chemistry for Living Biosystems
Institute of Chemistry Chinese Academy of Sciences
Beijing

Aptamers have attracted the attention of many researchers because of their high stability, high affinity and high selectivity. Over the past decades, considerable intensive exploration and research has been carried out in this area. These studies have led to the emergence of functionalized nanomaterials, which have suggested a more diverse range of potential applications. However, despite the many exciting and remarkable developments emerging at the moment, several challenges and issues remain to be addressed. Based on currently reported aptamer-functionalized nanomaterials (AFNs), this review highlights potential applications for AFN platforms in catalysis, detection, cellular analysis, imaging, and targeted drug delivery. We also focus on explaining controllable syntheses and the unique dynamic properties of AFNs. Finally, we discuss progress and the challenges associated with AFN applications in this field.

中文翻译：

用于生物应用的适体功能化纳米材料

适体由于其高稳定性，高亲和力和高选择性而吸引了许多研究者的注意。在过去的几十年中，在这一领域进行了大量的深入探索和研究。这些研究导致功能化纳米材料的出现，这表明潜在的应用范围更加广泛。然而，尽管目前出现了许多令人激动和令人瞩目的发展，但仍有一些挑战和问题有待解决。基于当前报道的适体功能化纳米材料（AFN），本综述重点介绍了AFN平台在催化，检测，细胞分析，成像和靶向药物递送中的潜在应用。我们还将重点介绍AFN的可控合成和独特的动态特性。最后，

更新日期：2020-02-28

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