The use of auxetic materials in tissue engineering,Biomaterials Science

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The use of auxetic materials in tissue engineering
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-02-27 , DOI: 10.1039/c9bm01928f
Paul Mardling _{1,

2,

3} , Andrew Alderson _{2,

3,

4} , Nicola Jordan-Mahy _{1,

2,

3} , Christine Lyn Le Maitre _{1,

2,

3}

Affiliation

A number of biological tissues have been reported as behaving in an auxetic manner, defined by a negative Poisson's ratio. This describes the deformation of tissue which expands in the axial and the transverse directions simultaneously while under uniaxial tension; and contracts axially and transversely upon uniaxial compression. The discovery of auxetic behaviour within biological tissues has implications for the recreation of the auxetic loading environment within tissue engineering. Tissue engineers strive to recreate the natural properties of biological tissue and in order to recreate the unique loading environment of cells from auxetic tissue, an auxetic scaffold is required. A number of studies have used a variety of auxetic scaffolds within tissue engineering. Investigation into the effect of auxetic micro-environments created by auxetic scaffolds on cellular behaviour has demonstrated an increased cellular proliferation and enhanced differentiation. Here, we discuss studies which have identified auxetic behaviour within biological tissues, and where cells have been cultured within auxetic scaffolds, bringing together current knowledge of the potential use of auxetic materials in tissue engineering applications and biomedical devices.

中文翻译：

增生材料在组织工程中的用途

据报道，许多生物组织表现为肿胀，表现为负泊松比。这描述了在单轴张力下同时沿轴向和横向扩展的组织变形。并在单轴压缩时轴向和横向收缩。在生物组织内的发胀行为的发现对组织工程中的发胀负荷环境的恢复具有影响。组织工程师致力于重建生物组织的自然特性，并且为了从贫血组织中重建细胞的独特加载环境，需要一个贫血支架。许多研究已经在组织工程学中使用了多种促生长支架。对由发胀支架产生的发胀微环境对细胞行为的影响的研究表明，细胞增殖增加且分化增强。在这里，我们讨论确定生物组织内的促生长行为以及在促生长支架内培养细胞的研究，从而将促生长材料在组织工程应用和生物医学设备中的潜在用途的最新知识结合在一起。

更新日期：2020-02-27

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