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Fluorescence chemosensing of meldonium using a cross-reactive sensor array.
Analyst ( IF 3.6 ) Pub Date : 2020-03-30 , DOI: 10.1039/d0an00209g Ergin Yalcin 1 , Cem Erkmen , Tugba Taskin-Tok , Mehmet Gokhan Caglayan
Analyst ( IF 3.6 ) Pub Date : 2020-03-30 , DOI: 10.1039/d0an00209g Ergin Yalcin 1 , Cem Erkmen , Tugba Taskin-Tok , Mehmet Gokhan Caglayan
Affiliation
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In this paper, we report a fluorescent sensor array approach for the urinary detection of a prohibited substance in sports, meldonium. Four chemosensors with ethidium bromide scaffolds were employed in this method. The interaction between meldonium and chemosensors was investigated by different techniques, such as ultraviolet-visible absorption and fluorescence spectroscopy, nuclear magnetic resonance, and mass spectrometry. Molecular dynamics simulation was also used to elucidate and support the interaction mechanisms between meldonium and the chemosensors. Differential responses obtained from the sensor array enabled the qualitative and quantitative analyses of meldonium with low error values. This method was able to detect and quantify meldonium at the nM level, fulfilling the requirements of minimum performance defined by the World Anti-Doping Agency.
中文翻译：
使用交叉反应传感器阵列对mel进行荧光化学传感。
在本文中，我们报告了一种荧光传感器阵列方法，用于尿液中检测体育运动中的违禁物质。该方法使用了四个带有溴化乙锭支架的化学传感器。通过不同的技术，例如紫外可见吸收和荧光光谱，核磁共振和质谱，研究了与化学传感器之间的相互作用。分子动力学模拟也被用来阐明和支持meldonium和化学传感器之间的相互作用机制。从传感器阵列获得的差分响应可以对具有低误差值的meldonium进行定性和定量分析。该方法能够检测和定量nM水平的meldonium，
更新日期：2020-02-28
中文翻译：
使用交叉反应传感器阵列对mel进行荧光化学传感。
在本文中，我们报告了一种荧光传感器阵列方法，用于尿液中检测体育运动中的违禁物质。该方法使用了四个带有溴化乙锭支架的化学传感器。通过不同的技术，例如紫外可见吸收和荧光光谱，核磁共振和质谱，研究了与化学传感器之间的相互作用。分子动力学模拟也被用来阐明和支持meldonium和化学传感器之间的相互作用机制。从传感器阵列获得的差分响应可以对具有低误差值的meldonium进行定性和定量分析。该方法能够检测和定量nM水平的meldonium，
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