Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly,Chemical Communications

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Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly
Chemical Communications ( IF 4.3 ) Pub Date : 2020/02/28 , DOI: 10.1039/d0cc00629g
Feng-Qing Li _{1,

2,

3,

4,

5} , Qi-Lin Yu _{1,

2,

3,

4,

5} , Yao-Hua Liu _{1,

2,

3,

4,

5} , Hua-Jiang Yu _{1,

2,

3,

4,

5} , Yong Chen _{1,

2,

3,

4,

5} , Yu Liu _{1,

2,

3,

4,

5}

Affiliation

In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.

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