Organization of primate amygdalar-thalamic pathways for emotions.,PLOS Biology

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Organization of primate amygdalar-thalamic pathways for emotions.
PLOS Biology ( IF 7.8 ) Pub Date : 2020-02-27 , DOI: 10.1371/journal.pbio.3000639
Clare Timbie _{1,

2} , Miguel Á García-Cabezas ₂ , Basilis Zikopoulos _{1,

3} , Helen Barbas _{1,

2}

Affiliation

Studies on the thalamus have mostly focused on sensory relay nuclei, but the organization of pathways associated with emotions is not well understood. We addressed this issue by testing the hypothesis that the primate amygdala acts, in part, like a sensory structure for the affective import of stimuli and conveys this information to the mediodorsal thalamic nucleus, magnocellular part (MDmc). We found that primate sensory cortices innervate amygdalar sites that project to the MDmc, which projects to the orbitofrontal cortex. As in sensory thalamic systems, large amygdalar terminals innervated excitatory relay and inhibitory neurons in the MDmc that facilitate faithful transmission to the cortex. The amygdala, however, uniquely innervated a few MDmc neurons by surrounding and isolating large segments of their proximal dendrites, as revealed by three-dimensional high-resolution reconstruction. Physiologic studies have shown that large axon terminals are found in pathways issued from motor systems that innervate other brain centers to help distinguish self-initiated from other movements. By analogy, the amygdalar pathway to the MDmc may convey signals forwarded to the orbitofrontal cortex to monitor and update the status of the environment in processes deranged in schizophrenia, resulting in attribution of thoughts and actions to external sources.

中文翻译：

灵长类动物杏仁核丘脑情绪通路的组织。

对丘脑的研究主要集中在感觉中继核上，但与情绪相关的通路的组织尚不清楚。我们通过测试这样的假设来解决这个问题：灵长类杏仁核的作用在某种程度上类似于刺激情感输入的感觉结构，并将这些信息传递到丘脑内侧核、大细胞部分（MDmc）。我们发现灵长类感觉皮层支配杏仁核部位，这些部位投射到 MDmc，而 MDmc 又投射到眶额皮层。与感觉丘脑系统一样，大杏仁核末梢支配 MDmc 中的兴奋性中继神经元和抑制性神经元，从而促进忠实地传递到皮质。然而，正如三维高分辨率重建所揭示的那样，杏仁核通过包围和隔离近端树突的大段来独特地支配一些 MDmc 神经元。生理学研究表明，在运动系统发出的通路中发现了大轴突末端，这些运动系统支配其他大脑中心，以帮助区分自我发起的运动和其他运动。类似地，通往 MDmc 的杏仁核通路可以将信号转发到眶额皮层，以监测和更新精神分裂症精神错乱过程中的环境状态，从而将思想和行为归因于外部来源。

更新日期：2020-03-02

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