当前位置: X-MOL 学术React. Funct. Polym. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Paclitaxel-loaded cyclodextrin-cored unimolecular micelles and their in vivo behavior
Reactive & Functional Polymers ( IF 4.5 ) Pub Date : 2020-02-27 , DOI: 10.1016/j.reactfunctpolym.2020.104542
Jing-jing Wang , Ying Qian , Chen Qian , Jing-yuan Yao , Xiao-lin Bi

Polymeric drug delivery systems for major diseases have experienced considerable development in the past decades due to the versatility of polymer chemistry. However, self-assembled micelles from multimacromolecules suffer from poor stability and imprecise architecture. Unimolecular micelles have many unique advantages, including high stability, accurate architecture and high drug loading. Herein, a series of well-defined, unimolecular, star-shaped, polymers (β-CD-s-PAA-PTX), with β-cyclodextrin as a core, poly(acrylic acid) (PAA) as branches, and the anticancer drug paclitaxel covalently linked to the branches, were synthesized. The β-CD-s-PAA-PTX can form unimolecular micelles in aqueous solutions, which was attributed to their amphiphilic structure. Drug loading increased with the increase of the molecular weight of the star-shaped polymer β-CD-s-polyacrylic acid (β-CD-s-PAA), and the maximum drug loading reached 59 wt%. The fate of the unimolecular micelles with different molecular weights in tumor-bearing mice was investigated. Unimolecular micelles with low molecular weights could not effectively accumulate in tumors, while high-molecular weight unimolecular micelles tended to accumulate in tumor sites. This study provided the effect of the molecular weights of the β-CD-cored unimolecular micelles on their in vivo behavior.



中文翻译:

紫杉醇负载环糊精核的单分子胶束及其体内行为

在过去的几十年中,由于高分子化学的多功能性,用于主要疾病的高分子药物递送系统已经取得了长足的发展。然而,来自多分子的自组装胶束具有差的稳定性和不精确的结构。单分子胶束具有许多独特的优势,包括高稳定性,准确的结构和高载药量。在此,以β-环糊精为核,聚丙烯酸(PAA)为支链的一系列定义明确的单分子星形聚合物(β -CD-s-PAA-PTX)和抗癌剂合成了与分支共价连接的药物紫杉醇。该β-CD-s-PAA-PTX可以在水溶液中形成单分子胶束,这归因于它们的两亲结构。随着星形聚合物β -CD-s-聚丙烯酸(β -CD-s-PAA)分子量的增加,药物载量增加,最大药物载量达到59 wt%。研究了荷瘤小鼠中不同分子量单分子胶束的命运。低分子量的单分子胶束不能有效地积聚在肿瘤中,而高分子量的单分子胶束则倾向于积聚在肿瘤部位。该研究提供了β -CD-核心的单分子胶束的分子量对其体内行为的影响。

更新日期:2020-02-27
down
wechat
bug