Extensive animal and human studies on chlorpyrifos (CPF) point to changes in a blood enzyme as its first biological effect, and governments and health groups around the world have used this effect in the determination of its safe dose. Preventing this first biological effect, referred to in risk assessment parlance as the critical effect, is part and parcel of chemical regulation in general and of CFP specifically. Rauh et al. (2011), one of the published studies from the Columbia Center for Children's Environmental Health (CCCEH), reported evidence of deficits in Working Memory Index and Full-Scale IQ in children at 7 years old as a function of prenatal CPF exposures that are much lower than levels causing cholinesterase inhibition. Since the raw data on which Rauh et. al. (2011) publicly-funded (in part) findings were based have not been made available despite repeated requests, we show extracted data in Fig. 1A and 1E of Rauh et al. (2011), and plotted these extracted data as response versus log dose, a common risk assessment approach. Surprisingly, a significant portion of the data stated to be available in Rauh et al. (2011) were not found in these published figures, perhaps due to data point overlay. However, the reported associations of chlorpyrifos levels with Working Memory and Full Scale IQ were also not replicated in our analysis due perhaps to this missing data. Multiple requests were made to Rauh et al. (2011) for access to data from this, in part, publicly funded study, so that confirmation could be attempted. This general lack of data and inconsistency with cholinergic responses in other researches raises concerns about the lack of data transparency.

中文翻译：

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关于毒死rif某些流行病学数据的评论。

大量的动物和人体对毒死rif（CPF）的研究表明，血液酶的变化是其最初的生物学效应，世界各地的政府和卫生组织已在确定其安全剂量时使用了这种效应。预防这种第一种生物学效应，在风险评估中被称为关键效应，通常是化学法规尤其是CFP不可或缺的一部分。Rauh等。（2011）是哥伦比亚儿童环境卫生中心（CCCEH）发表的一项研究，报告了7岁儿童的工作记忆指数和全面智商不足的证据，这与产前CPF暴露的影响有关。低于导致胆碱酯酶抑制的水平。由于Rauh等人的原始数据。等 （2011年）尽管有重复的请求，但仍未获得公共资助（部分）的发现，我们在Rauh等人的图1A和1E中显示了提取的数据。（2011年），并绘制了这些提取的数据，将其作为响应与对数剂量的比较，这是一种常见的风险评估方法。出乎意料的是，Rauh等人中声称有相当一部分数据可用。在这些已发布的图中未找到（2011），可能是由于数据点覆盖。然而，也许由于缺少这些数据，毒死rif水平与工作记忆和全智商的相关报道也没有在我们的分析中重复。向Rauh等提出了多个请求。（2011年），以部分地从公共研究中获取数据，以便尝试进行确认。