Small-molecule inhibitors are a key resource in the cell signaling toolbox. However, because of their global distribution in the cell, they cannot provide a refined understanding of signaling at distinct subcellular locations. Bucko and colleagues have designed a novel tool to localize inhibitors to specific protein scaffolds, opening a new avenue to study localized kinase activity.

中文翻译：

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 药理学目标。


小分子抑制剂是细胞信号传导工具箱中的关键资源。然而，由于它们在细胞中的全局分布，它们无法提供对不同亚细胞位置的信号传导的精确理解。 Bucko 及其同事设计了一种新颖的工具，将抑制剂定位于特定的蛋白质支架，为研究局部激酶活性开辟了一条新途径。