Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have excised latent integrated proviral DNA or removed infected cells from infected persons. These efforts included, but are not limited to, broadly neutralizing antibodies, "shock" and "kill" latency-reversing agents, innate immune regulators, and sequential long-acting antiretroviral nanoformulated prodrugs and CRISPR-Cas9 gene editing. While, the latter, enabled the complete excision of latent HIV-1 from the host genome success was so far limited. We contend that improvements in antiretroviral delivery, potency, agent specificity, or combinatorial therapies can provide a pathway towards complete HIV elimination.

中文翻译：

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消除人类免疫缺陷病毒的途径。


抗逆转录病毒疗法（ART）可抑制人类免疫缺陷病毒（HIV）感染。寻求将病毒抑制转化为消除的研究已经产生了新型免疫、化学和分子抗病毒药物。然而，迄今为止，还没有人从感染者身上切除潜伏整合的前病毒 DNA 或去除受感染的细胞。这些努力包括但不限于广泛中和抗体、“休克”和“杀死”潜伏期逆转剂、先天免疫调节剂以及连续长效抗逆转录病毒纳米制剂前药和 CRISPR-Cas9 基因编辑。而后者从宿主基因组中完全切除潜伏的 HIV-1 的成功迄今为止还很有限。我们认为，抗逆转录病毒递送、效力、药物特异性或组合疗法的改进可以提供一条彻底消除艾滋病毒的途径。