Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have excised latent integrated proviral DNA or removed infected cells from infected persons. These efforts included, but are not limited to, broadly neutralizing antibodies, "shock" and "kill" latency-reversing agents, innate immune regulators, and sequential long-acting antiretroviral nanoformulated prodrugs and CRISPR-Cas9 gene editing. While, the latter, enabled the complete excision of latent HIV-1 from the host genome success was so far limited. We contend that improvements in antiretroviral delivery, potency, agent specificity, or combinatorial therapies can provide a pathway towards complete HIV elimination.

中文翻译：

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消除人类免疫缺陷病毒的途径。

抗逆转录病毒疗法（ART）抑制人类免疫缺陷病毒（HIV）感染。试图将病毒抑制转化为消除的研究已经产生了新型的免疫，化学和分子抗病毒剂。但是，迄今为止，还没有人切除潜在的整合前病毒DNA或从感染者身上清除感染的细胞。这些努力包括但不限于广泛中和抗体，“休克”和“杀灭”潜伏期逆转剂，先天免疫调节剂，连续长效抗逆转录病毒纳米制剂前药和CRISPR-Cas9基因编辑。尽管后者使得能够从宿主基因组中完全切除潜伏的HIV-1的成功到目前为止是有限的。我们认为，抗逆转录病毒药物的递送，效力，药物特异性，