Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery,Journal of Materials Chemistry B

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Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/02/27 , DOI: 10.1039/c9tb02465d
Qian Zhang _{1,

2,

3,

4} , Yun Chen _{1,

2,

3,

4} , Ruilin Lu _{2,

3,

4,

5} , Yongchao Yao _{1,

2,

3,

4} , Chuanqi Li _{1,

2,

3,

4} , Yunlong Yu _{1,

2,

3,

4} , Shiyong Zhang _{1,

2,

3,

4,

5}

Affiliation

The cross-linked small-molecule micelles (cSMs) have found applications in many fields but their low loading capacity and non-fluorescence property hindered their further development. Herein, water-soluble organic nanoparticles were applied as templates to “stretch” the hydrophobic core of cSMs and photo-cross-linking was employed to supply photoluminescence. The resulting cross-linked small-molecule capsules (cSCs) not only reserve the superior properties of cSMs of accurate monomer, easy functionalization and robust stability, but also achieve high drug loading capacity and excitation wavelength-dependent fluorescence, where the drug loading contents (DLCs) for various hydrophobic drugs were more than 30-fold higher than that of cSMs, and the maximum quantum yield could be as high as 12.0%. Featuring these superiorities, the cSCs hold promising potential in many fields and an example of doxorubicin-loaded cSCs (DOX@cSCs) for multichannel imaging-guided drug delivery is shown in this work.

中文翻译：

具有依赖于激发波长的光致发光和高载量的交联小分子胶囊：设计，合成及在影像引导药物输送中的应用

交联的小分子胶束（cSMs）已在许多领域中得到应用，但是它们的低载量和非荧光性质阻碍了它们的进一步发展。在本文中，将水溶性有机纳米粒子用作模板以“拉伸” cSMs的疏水核，并采用光交联来提供光致发光。所得的交联小分子胶囊（cSCs）不仅保留了cSMs的优良特性，包括准确的单体，容易的功能化和强大的稳定性，而且还实现了高载药量和激发波长依赖性荧光，其中载药量各种疏水性药物的DLCs均比cSMs高30倍以上，最大量子产率可高达12.0％。具有这些优势

更新日期：2020-04-01

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