Unlocking the door for ERAD.,Nature Cell Biology

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Unlocking the door for ERAD.
Nature Cell Biology ( IF 17.3 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41556-020-0476-1
Miguel Betegon ₁ , Jeffrey L Brodsky ₁

Affiliation

Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by autoubiquitination and a soluble ERAD substrate.

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