BACKGROUND The purpose of this study is to evaluate the prognostic factors for sperm retrieval and determine if Y chromosome deletion is associated with deleterious effects on spermatogenesis in non-mosaic Klinefelter patients. Whether Y chromosome deletion determines the sperm retrieval rate in non-mosaic Klinefelter patients has not yet been addressed. METHODS We retrospectively collected medical records of azoospermic patients from Sep 2009 to Dec 2018, and enrolled 66 non-mosaic 47, XXY patients who were receiving mTESE. The predictive values of patients age, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin, estradiol and Y chromosome deletion were assessed for successful sperm recovery. RESULTS Testicular sperm recovery was successful in 24 (36.4%) of 66 men. The mean age (36.0 vs. 36.6 years), and levels of FSH (30.0 vs 36.9 IU/L), LH (17.7 vs 21.9 IU/L), testosterone (2.4 vs. 2.1 ng/ml), prolactin (9.1 vs. 8.8 ng/ml), and estradiol (19.4 vs. 22.3 pg/ml) did not show any significant difference when comparing patients with and without successful sperm retrieval. Partial deletion of azoospermic factor c (AZFc) was noted in 5 (20.8%) of 24 patients with successful sperm retrieval, including three b2/b3 and two gr/gr deletion cases, whereas 4 (9.5%) of 42 patients with unsuccessful sperm retrieval were noted to have AZFc partial deletion (one b2/b3, one sY1206 and two gr/gr deletion), though the difference was not statistically significant (p = 0.27). CONCLUSION According to present results, age and AZFc partial deletion status should not be a deterrent for azoospermic males with non-mosaic Klinefelter syndrome to undergo mTESE.

中文翻译：

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接受非解剖性Klinefelter显微切除睾丸精子的非镶嵌患者的部分AZFc缺失会影响精子回收率吗？

背景技术这项研究的目的是评估精子取回的预后因素，并确定Y染色体缺失是否与非镶嵌Klinefelter患者精子发生的有害影响有关。Y染色体缺失是否决定非镶嵌Klinefelter患者的精子回收率尚未得到解决。方法回顾性收集2009年9月至2018年12月无精子症患者的病历，纳入66例接受mTESE治疗的47名非马赛克性XXY患者。评估患者年龄，血清卵泡刺激素（FSH），黄体生成素（LH），睾丸激素，催乳激素，雌二醇和Y染色体缺失对精子成功恢复的预测价值。结果66名男性中有24名（36.4％）的睾丸精子恢复成功。平均年龄（36.0岁对36.6岁），FSH（30.0 vs 36.9 IU / L），LH（17.7 vs 21.9 IU / L），睾丸激素（2.4 vs. 2.1 ng / ml），催乳素（9.1 vs. 8.8 ng / ml）和雌二醇（19.4 vs. 。22.3 pg / ml）在比较有和没有成功精子回收的患者时没有显示任何显着差异。在成功完成精子修复的24例患者中，有5名（20.8％）的无精子因子c（AZFc）部分缺失，包括3例b2 / b3和2例gr / gr缺失，而42例精子不成功的患者中有4例（9.5％）检索发现有AZFc部分缺失（一个b2 / b3，一个sY1206和两个gr / gr缺失），尽管差异无统计学意义（p = 0.27）。结论根据目前的结果，年龄和AZFc部分缺失状态不应对无马赛克Klinefelter综合征的无精子症男性进行mTESE产生威慑作用。