Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

中文翻译：

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瞬时自噬抑制作用促进肿瘤发生：药理自噬抑制剂的危险信号？

最近的发现表明自噬的瞬时遗传抑制促进了小鼠中与年龄相关的病理。自噬修复可有效抵消此类疾病，但也会加剧各种实体瘤和血液肿瘤的发生率。这些数据可能会进一步抑制自噬抑制在癌症治疗中的临床潜力。