Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnancy. Moreover, the placenta expresses the transporters of the lactic acid. While several studies have described the role of lactic acid in the tumor microenvironment, especially lactic acid's modulation of immune cells, the role of lactic acid produced during pregnancy is still unclear. In this paper, we reviewed the scientific evidence detailing the effects of lactic acid in the tumor microenvironment. Based on the influence of the lactic acid on immune cells and tumors, we proposed that lactic acid released in the unique uterine environment could have similar effects on the trophoblast cells and immune cells during the early pregnancy.

有氧糖酵解是肿瘤共有的公认特征，导致乳酸在其局部微环境中积累。像肿瘤一样，在孕早期，胚泡，胎盘，滋养细胞和蜕膜免疫细胞也可以通过有氧糖酵解产生大量乳酸。此外，胎盘表达乳酸的转运蛋白。尽管有几项研究描述了乳酸在肿瘤微环境中的作用，特别是乳酸对免疫细胞的调节作用，但怀孕期间产生的乳酸的作用仍不清楚。在本文中，我们回顾了详细证明乳酸在肿瘤微环境中作用的科学证据。根据乳酸对免疫细胞和肿瘤的影响，