Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. Hippo-YAP pathway regulates cell proliferation, survival, differentiation and is involved in diverse life processes, including tissue homeostasis and tumor suppression. Emerging discoveries elucidated that the components of Hippo-YAP pathway, such as MST1/2, NDR1/2, and YAP/TAZ played crucial regulatory roles in innate immunity. Meanwhile the innate immune signaling also exhibited regulatory effect on Hippo-YAP pathway. As for the importance of these two pathways, it would be interesting to figure out the deeper biological implications of their interplays. This review focuses on the regulation between Hippo-YAP pathway and innate immune signaling. We also propose the possible contribution of these interplays to tumor development.

病原体相关分子模式（PAMPs）的识别触发抗病毒干扰素和促炎细胞因子的表达，这是宿主防御微生物病原体入侵的前沿。Hippo-YAP途径调节细胞增殖，存活，分化，并参与多种生命过程，包括组织稳态和肿瘤抑制。新兴发现阐明了Hippo-YAP途径的成分，例如MST1 / 2，NDR1 / 2和YAP / TAZ在先天免疫中起着至关重要的调节作用。同时，先天免疫信号也对Hippo-YAP途径表现出调节作用。至于这两种途径的重要性，找出它们相互作用的更深层次的生物学意义将是很有趣的。这篇综述着重于河马-YAP途径和先天免疫信号之间的调节。我们还提出了这些相互作用对肿瘤发展的可能贡献。