The present study suggests that insulin resistance has no association with bone quantity, but quality. INTRODUCTION The literature has contradictory results concerning the influence of insulin resistance on bone. The present study sought to evaluate the association of insulin resistance and adipose tissue with either bone mineral density or the trabecular bone score. METHODS The study included 56 individuals (36 women and 20 men): age = 46.6 ± 14.2 years, weight = 67.8 ± 10.9 kg, height = 1.65 ± 0.10 m and BMI = 24.8 ± 3.9 kg/m2. The investigational protocol included biochemical determinations and bone assessment by dual X-ray absorptiometry for evaluation of bone mineral density and trabecular bone score. Magnetic resonance was employed to estimate visceral, subcutaneous and bone marrow adipose tissues, as well as intrahepatic lipids. RESULTS The bone mineral density of the lumbar spine, femoral neck and total hip were not associated with insulin resistance-related parameters [visceral adipose tissue, intrahepatic lipids and homeostatic model assessment of insulin resistance (HOMA-IR)]. In contrast, there was a negative relationship between the trabecular bone score and all these components. The association between the trabecular bone score and HOMA-IR was reinforced after adjustment for age and BMI. Marrow adipose tissue was negatively associated with both bone mineral density and trabecular bone score. CONCLUSIONS The present study shows that the trabecular bone score is negatively associated with marrow adipose tissue, insulin resistance, visceral adipose tissue and intrahepatic lipid measurements. Additionally, there was a negative relationship between saturated lipids in marrow adipose tissue and the trabecular bone score. These results encourage further studies to investigate the role of the trabecular bone score exam in the clinical evaluation of osteoporosis in conditions of insulin resistance.

中文翻译：

---

胰岛素抵抗不利地影响骨骼质量而不是数量：骨骼与脂肪组织之间的关系。

本研究表明胰岛素抵抗与骨骼数量无关，但与骨骼质量有关。引言关于胰岛素抵抗对骨骼的影响，文献有矛盾的结果。本研究试图评估胰岛素抵抗和脂肪组织与骨矿物质密度或小梁骨评分之间的关​​系。方法该研究包括56名个体（36名女性和20名男性）：年龄= 46.6±14.2岁，体重= 67.8±10.9 kg，身高= 1.65±0.10 m和BMI = 24.8±3.9 kg / m2。研究方案包括通过双X射线吸收法进行生化测定和骨评估，以评估骨矿物质密度和小梁骨评分。磁共振被用来估计内脏，皮下和骨髓的脂肪组织，以及肝内脂质。结果腰椎，股骨颈和全髋关节的骨矿物质密度与胰岛素抵抗相关参数[内脏脂肪组织，肝内脂质和胰岛素抵抗稳态模型评估（HOMA-IR）]无关。相反，小梁骨评分与所有这些成分之间存在负相关关系。调整年龄和BMI后，小梁骨评分与HOMA-IR之间的关联得到加强。骨髓脂肪组织与骨矿物质密度和小梁骨评分均呈负相关。结论本研究表明，小梁骨评分与骨髓脂肪组织，胰岛素抵抗，内脏脂肪组织和肝内脂质测量值呈负相关。另外，骨髓脂肪组织中的饱和脂质与小梁骨评分之间呈负相关。这些结果鼓励进行进一步的研究，以探讨小梁骨评分检查在胰岛素抵抗条件下对骨质疏松症的临床评估中的作用。