Anorexia, body wasting, inflammation, muscle, and adipose tissue loss are hallmarks of cancer cachexia, a syndrome that affects the majority of cancer patients, impairing their ability to endure chemotherapeutic therapies and reducing their lifespan. In the last 10 years, alterations of protein turnover and impairment of adult myogenesis have been proposed as major contributing factors.

中文翻译：

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Interleukin-4 给药可改善携带结肠癌的小鼠的肌肉功能、成年肌生成和寿命。

厌食、身体消瘦、炎症、肌肉和脂肪组织损失是癌症恶病质的标志，这是一种影响大多数癌症患者的综合征，削弱了他们忍受化疗治疗的能力并缩短了他们的寿命。在过去的 10 年中，蛋白质周转的改变和成体肌生成的损害被认为是主要的促成因素。